WebSep 14, 2009 · Selective lowering of amyloid-β levels with small-molecule γ-secretase inhibitors is a promising therapeutic approach for Alzheimer’s disease. In this work, we developed a high throughput assay for screening of γ-secretase inhibitors with endogenous γ-secretase and a fluorogenic substrate. The IC50 values of known γ-secretase inhibitors … WebZika virus (ZIKV) pandemic and its implication in congenital malformations and severe neurological disorders had created serious threats to global health. ZIKV is a mosquito …
High-Throughput Activity Assay for Screening Inhibitors …
WebApr 18, 2024 · Development of a High-Throughput Screening Assay for AR-v Inhibitors To demonstrate the suitability of TRE-x-GRE 2 -AR-v cells for drug screening, it was … WebMar 24, 2024 · The highly validated pharmacological target main protease M pro was selected and high throughput virtual screening of African Natural Products Databases to identify the most potent inhibitors with the best pharmacological properties was performed to identify new-targeted drugs to overcome the resistance concern. Abstract With the … immersive king tut exhibit houston
High-Throughput NanoBiT-Based Screening for Inhibitors of HIV-1 …
WebMar 9, 2015 · In the high-throughput screening (HTS) format, SAMHD1 reactions were performed in a total volume of 40 µL (50 mM Tris-HCl [pH 7.5], 50 mM KCl, ... In summary, we have validated a robust high-throughput assay for screening for inhibitors of SAMHD1. The assay has a large signal-to-background and minimal well-to-well variability and is ... WebAssay development and high-throughput screening for small molecule inhibitors of a Vibrio cholerae stress response pathway Laura Stanbery, Jyl S Matson Department of Medical Microbiology and Immunology, College of Medicine and Life Sciences, The University of Toledo, Toledo, OH, USA Abstract: Antibiotics are important adjuncts to oral rehydration … WebAnother example is the thieno[2,3-D]pyrimidine substructure, which was enriched from initially 0.5% to 7%. These examples show that the high-throughput screening approach … immersive king tut phoenix dates