WebApr 6, 2024 · Cytarabine is embryotoxic and teratogenic when administered to rodents during the period of organogenesis at clinically relevant doses. It is reported that cytarabine causes developmental toxicity, including damage to the developing brain, when administered during the peri- and postnatal period. WebThe aim of this randomized phase II study was to investigate the optimal timing of the administration of thrombopoietin to prevent cytarabine-induced thrombocytopenia. Fifty-two patients who were scheduled for high-dose cytarabine treatment were randomly assigned to receive either the standard proph …
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WebNov 23, 2024 · Very common (10% or more): Cytarabine syndrome (e.g., fever, myalgia, bone pain, occasionally chest pain, exanthema, maculopapular rash, conjunctivitis, nausea, malaise) Uncommon (0.1% to 1%): Myalgia, joint pain [ Ref] Metabolic Common (1% to 10%): Anorexia, hyperuricemia [ Ref] Psychiatric WebImmune thrombocytopenia (ITP) can coexist with autoimmune thyroid disease. ... (ETP), and cytarabine (Ara-C) (MEC) is a frequently used salvage therapy for acute leukemia, but has been associated ... list three common mood disorders
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WebApr 13, 2024 · The V205M mutation was identified in two half brothers whose mother developed a mild thrombocytopenia during pregnancy and was heterozygous for the allele. ... event-free survival and overall survival approaching 80%. 69 The increased sensitivity of DS-AMKL blasts to high-dose cytarabine-based therapy has been attributed to … WebMar 21, 2024 · SIDE EFFECTS Expected Reactions. Because cytarabine is a bone marrow suppressant, anemia, leukopenia, thrombocytopenia, megaloblastosis and reduced reticulocytes can be expected as a result of administration with cytarabine.The severity of these reactions are dose and schedule dependent. Cellular changes in the morphology … WebThe main toxic effect of cytarabine is bone marrow suppression with leukopenia, thrombocytopenia and anemia. Less serious toxicity includes nausea, vomiting, diarrhea and abdominal pain, oral ulceration and hepatic dysfunction. ... Cytarabine Injection, an antineoplastic agent, is a sterile preserved solution for intravenous or subcutaneous ... impacts of climate change on brazil